John Higgins

Massachusetts General Hospital
Center for Systems Biology
185 Cambridge St
Boston, MA 02114
Tel: 617-643-6129
Email: JMHIGGINS@PARTNERS.ORG

Website:

http://higgins.hms.harvard.edu
Lab Size: Between 5 and 10

Summary

The Higgins lab combines medical insight, dynamic systems theory, and experiments utilizing microfluidics, video processing, flow cytometry, simulation, and large-scale analysis of medical databases to measure and model the dynamics of human pathophysiologic processes.

My research focuses on human pathophysiologic processes. I am interested in developing mathematical descriptions of complex human disease phenotypes and how they change over time. Pathophysiology may be described at the molecular, cellular, tissue, and organismal levels and may show clinically significant variation over time scales ranging from seconds to years. My research combines clinical and pathophysiologic insight with dynamical systems theory in order to (1) advance fundamental understanding of the dynamics of human pathophysiology, and (2) improve patient diagnosis, monitoring, and treatments.