#  Michael Springer 

Professor of Systems Biology 

 

 

 



   ![springer](/sites/g/files/omnuum12386/files/styles/hwp_4_5__320x400/public/2026-08/springer.png?itok=A1AZm-o0) 

 



 





 

Harvard Medical School, Department of Systems Biology  
Alpert Building, Room 120  
200 Longwood Ave.  
Boston, MA 02115  
**Tel**: 617-432-7391  
**Email**: [michael\_springer@hms.harvard.edu](mailto:michael_springer@hms.harvard.edu)

#### **Website**

[springerlab.org](https://springerlab.org/)   
**Lab Size**: Between 5 and 10

#### **Summary**

The Springer lab is interested in how evolution shapes and constrains how organisms respond to their environment. They analyze cellular responses in several related yeast species using a combination of in vivo fluorescence, synthetic and genetic approaches, and numerical and analytical modeling.

While we have a great mechanistic understanding of how the information encoded in DNA is converted through mRNA to protein, we have a limited understanding of the quantitative relationship between genotype and phenotype. We do not know whether properties such as protein abundance are under strong selective constraints and therefore it is difficult to interpret the myriad of changes that are evident between related individuals and species. Using a combination of theoretical, genomic, and proteomic approaches we are exploring in both a high throughput and direct fashion how evolution has changed (comparative evolution), could have changed (synthetic evolution), and does changes (experimental evolution) quantitative features of networks in multiple yeast species under different selective regimes.



 

 

 





 

 

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